Physics 147C is devoted to three major areas, 1. Biophysics with Light, 2. Thermal Physics and Hydrodynamics with a focus on the circulation and on biological transport phenomena, 3. Bioelectromagnetism including the electrical properties of cell membranes, nerves and muscles. Each of the three parts will consist of six lectures and an exam. Because of the constraints of the lecturers' schedules, one of the areas of study will be divided into two parts. The exams will be on May 11 (Biophysics with Light), May 25 (Thermal Physics) and during final exam week (Biolelectromagnetism).
The course will meet at 11-12:20 PM Tuesday and Thursday in 4135 Frederick Reines Hall (PS2). The lecturers for this quarter are Bruce Tromberg (Beckmann Laser Institute), Nancy Allbritton (Biophysics and Physiology), Mark Mandelkern (Physics), Joie Jones and Fred Greensite (Radiological Sciences).
The text is Intermediate Physics for Medicine and Biology by Russell K. Hobbie. AIP Press/Springer. Further references and materials will be provided by the lecturers.
Thermal Physics and Biological Transport
Week 1: Hydrostatics and Hydrodynamics-Jones Hydrostatics Steady Flow, Bernoulli's Theorem Viscous Flow in a Tube, Poiseuille Equation, Mach Number Turbulent Flow, Reynolds Number The Human Circulatory System
Week 2: Equilibrium Thermal Physics-Mandelkern Thermal Equilibrium Microstates, Entropy Temperature, Chemical Potential Boltzmann Factor, Nernst Equation Gibbs Free Energy, Chemical Reactions, Solutions
Week 3: Transport Phenomena-Mandelkern Stokes Law, Motion in a Liquid Diffusion, Fick's Laws Einstein Relation between Diffusion Coefficient and Viscosity Perfusion, Transport of Solutes to and from Cells Osmotic Pressure Volume and Solute Transport through Membranes Clinical Examples-Capillary Function, Edema, Osmotic Fragility
References Hobbie -Intermediate Physics for Medicine and Biology Feynman-The Feynman Lectures on Physics, Volume II.
Biophysics with Light
Lecture 1: Fundamentals of Light/Matter Interactions -Tromberg Absorption Luminescence Scattering
Lecture 2: Vision-Allbritton Image formation Visual pigments Photon detection
Lecture 3: Fundamentals of Instrumentation and Measurements-Tromberg Individual Components sources detectors dispersion Integrated Systems spectrometers: absorption and emission microscopes: laser scanning
Lecture 4: Optical Measurements of Molecular Force and Distance-Allbritton Molecular motors Energy transfer
Lecture 5: Fundamentals of Bulk Tissue Measurements-Tromberg Tissue optics Photon Migration Pulse/modulation techniques
Lecture 6: Pulse Oximetry-Allbritton Hemoglobin physiology Blood transport Saturation measurements
Bioelectromagnetic Phenomena-Greensite
Impulses in Nerve and Muscle Cells
Transmembrane potential and charge distribution in resting cells Pump-leak mechanism Capacitance, conductance, resistance of the resting cell Electrically large v. small cells Telegrapher's equation, conduction velocity, electrotonus(passive spread) Voltage clamp experiments, Hodgkin-Huxley model, action potential. Propagating impulse, saltatory conduction Solutions of the Telegrapher's equation Capacitance and dielectric constant for membranes Intercellular transmission Recording transmembrane potential by external means
Exterior potentials from the electrical activity of cells. Detecting small bioelectric fields Electrodes The heart and electrocardiogram (ECG) The MCG, EEG, MCG, EMG
Biomagnetism and biological effects Magnetic fields from cells Electrically silent biomagnetic fields Detecting weak biomagnetic fields, the SQUID Brain: relative sensitivity of magnetic vs. electric field measurements Biomagnetic measurements in lung, heart, and liver Noise Biological effects of DC and powerline fields Thermal v. non-thermal effects, mechanisms Biological effects of non-ionizing radiation (RF/microwave)
Cellular Electromagnetism Donnan equilibrium Potential change and ion concentrations at the cell membrane Ion currents, Nernst-Planck and Goldman equations Membrane channels
References: Hobbie, Feynman Lectures
| Last revised: November 10, 1998 | http://eee.uci.edu/99s/47390/syllabus.html |
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